H(+)/Cl(-) exchange transporter 3

BE0013365ProteinHumansCLCN3

Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
CLCN3
UniProtKB entry
P51790Swiss-Prot
Cellular location
Early endosome membrane
Residues / weight
818 residues · 90,965 Da
Also known as
Chloride channel protein 3 · Chloride transporter ClC-3 · ClC-3

Resolves to

Protein
UniProtP51790UniProt nameCLCN3_HUMAN
Gene
HGNCHGNC:2021NCBI Gene1182GeneCardsCLCN3
Pharmacology
IUPHAR/GtoPdb702KEGGhsa:1182
Structure
PDB9DNWPDB9DNXPDB9DNY
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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32GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on H(+)/Cl(-) exchange transporter 3, and which indications are they being tested in?

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