Sestrin-2

BE0013521ProteinHumansSESN2

Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). It is acted on by 1 drug in DrugBank.

Gene name
SESN2
UniProtKB entry
P58004Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
480 residues · 54,493 Da
Also known as
1.11.1.- · Hi95 · Hypoxia-induced gene · SEST2

Resolves to

Protein
UniProtP58004UniProt nameSESN2_HUMAN
Gene
HGNCHGNC:20746NCBI Gene83667GeneCardsSESN2
Pharmacology
KEGGhsa:83667
Structure
PDB5CUFPDB5DJ4PDB5T0N
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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37GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Sestrin-2, and which indications are they being tested in?

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