NV-5138

DB19180InvestigationalSmall molecule

NV-5138 is under investigation in clinical trial NCT06235905 (Open-label of SPN-820 in Adults With Major Depressive Disorder).

Mechanism: Pharmacologically active on Serine/threonine-protein kinase mTOR and Sestrin-2
Curator reviewed
Formula / weight: C₇H₁₃F₂NO₂ · 181.183 g/mol (avg)
Also known as: ((S)-2-AMINO-5,5-DIFLUORO-4,4-DIMETHYLPENTANOIC ACID · Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2s)-
Code names: NV-5138 · SPN-820

Resolves to

Compound

Structure

InChIKeyHRFIMCJTDKEPPV-BYPYZUCNSA-NSMILESCC(C)(C[C@H](N)C(O)=O)C(F)F

Targets

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with NV-5138, and which of those have an active Phase 3 trial?

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