Mucin-5AC

BE0013878ProteinHumansMUC5AC

Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). It is acted on by 3 drugs in DrugBank.

Gene name
MUC5AC
UniProtKB entry
P98088Swiss-Prot
Cellular location
Secreted
Residues / weight
5,654 residues · 585,564 Da
Also known as
Gastric mucin · Major airway glycoprotein · MUC-5AC · MUC5 · Mucin-5 subtype AC, tracheobronchial

Resolves to

Protein
UniProtP98088UniProt nameMUC5A_HUMAN
Gene
HGNCHGNC:7515NCBI Gene4586GeneCardsMUC5AC
Pharmacology
KEGGhsa:4586
Structure
PDB5AJNPDB5AJOPDB5AJP
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mucin-5AC, how selective are they, and which programs against it are still in active trials?

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