Bromelains
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Bromelains
- Accession Number
- DB13281
- Description
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors 2. It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins 1 and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.
- Type
- Biotech
- Groups
- Investigational
- Synonyms
- Bromelain
- Bromelain juice
- Bromelain protease
- Bromelaina
- Bromelaines
- Pineapple protease
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataBromanase 1800 Tab 225mg Tablet Oral Nf Formulas Inc. 1984-12-31 2000-06-21 Canada 
Bromelain 250 Capsule Oral Thorne Research Inc. 1984-12-31 2005-08-26 Canada Bromelain 500 (300gdu/capsule) Capsule Oral Quest Vitamins A Div Of Purity Life Health Products 1993-12-31 1999-08-30 Canada Bromelain 500mg Tablets Tablet Oral Jamieson Laboratories Ltd 1996-09-10 2000-09-08 Canada Bromelain Pineapple Enzyme 50 Mg Nu Life Tablet Oral Nu Life Nutrition Ltd. 1963-12-31 2000-03-03 Canada Bromelain Pwr Powder Oral Everest Pharmaceuticals Ltd. 1979-12-31 1999-07-14 Canada Bromelain Tab 50mg Tablet Oral Country Health Laboratories Ltd. 1982-12-31 2001-07-27 Canada Bromelain Tab 50mg Tablet Oral Albi Imports Ltd. 1979-12-31 1996-09-09 Canada Bromelain Tablet 500mg Tablet Oral Royal Bodycare Canada Inc. 1993-12-31 2001-08-07 Canada Gnc Natural Brand Tm Bromelain 100000gdu Tablet Oral General Nutrition Canada Inc. 2002-10-20 2007-08-01 Canada Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Alka-pan Tablets Bromelains (50 mg) + Betaine hydrochloride (20 mg) + Ox bile extract (35 mg) + Pancrelipase (135 mg) + Papaya (125 mg) Tablet Oral Morter Healthsystem Not applicable Not applicable Canada Body Tropics Plus Tab Bromelains (50 mg) + Choline bitartrate (500 mg) + Inositol (250 mg) + Pyridoxine (25 mg) + Racemethionine (100 mg) Tablet Oral Pro Shop Inc. 1994-12-31 2008-08-02 Canada Bromelain and Papain Tab Bromelains (75 mg) + Papain (35 mg) Tablet Oral Vita Health Products Inc 1978-12-31 2002-07-31 Canada Chewable Enzymes Tablets Bromelains (15 mg) + Pancrelipase amylase (5 mg) + Papain (100 mg) Tablet Oral Gahler Enterprises Ltd. 1988-12-31 2002-07-17 Canada Cilobana Cpa Tab Bromelains (4 mg) + Ascorbic acid (150 mg) + Citrus bioflavonoids (75 mg) + Hesperidin (75 mg) + Vitamin A (10000 unit) Tablet Oral Anabolic Laboratories Inc. 1968-12-31 1996-10-02 Canada Pancreatin and Enzyme Formula - Tablet Bromelains (50 mg) + Ox bile extract (5 mg) + Pancrelipase (350 mg) + Pancrelipase lipase (50 mg) + Pepsin (100 mg) Tablet Oral Health Wise Nutrition Inc. 1997-08-15 2000-07-29 Canada Papaya Bromelain Mycozyme Bromelains (45 mg) + Pancrelipase amylase (30 mg) + Papain (30 mg) Tablet Oral Alive Vitamins 1985-12-31 2002-07-12 Canada
Categories
- ATC Codes
- D03BA03 — Bromelains
- D03BA — Proteolytic enzymes
- D03B — ENZYMES
- D03 — PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
- D — DERMATOLOGICALS
- Drug Categories
- Classification
- Not classified
Chemical Identifiers
- UNII
- U182GP2CF3
- CAS number
- 9001-00-7
References
- General References
- Taussig SJ: The mechanism of the physiological action of bromelain. Med Hypotheses. 1980 Jan;6(1):99-104. [PubMed:7382892]
- Pavan R, Jain S, Shraddha, Kumar A: Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203. Epub 2012 Dec 10. [PubMed:23304525]
- Brien S, Lewith G, Walker A, Hicks SM, Middleton D: Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6. [PubMed:15841258]
- External Links
- PubChem Substance
- 347911446
- 1752
- Wikipedia
- Bromelains
- AHFS Codes
- 56:16.00 — Digestants
- 44:00.00 — Enzymes
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Supportive Care Dental Decay / Plaque, Dental 1 2 Unknown Status Treatment Malignancies 1 1, 2 Not Yet Recruiting Treatment Adenocarcinoma, Mucinous / Malignant Peritoneal Neoplasm / Mucinous Tumor / Pseudomyxoma Peritonei 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Tablet Oral Powder Oral Tablet Oral Powder Cutaneous 2 G Powder Cutaneous 5 G Tablet, coated Oral 35000 U FIP - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created on June 23, 2017 14:39 / Updated on October 25, 2020 09:16
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