This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
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Identification
- Summary
Bromelains is a protease indicated in the treatment of inflammation and for eschar removal.
- Generic Name
- Bromelains
- DrugBank Accession Number
- DB13281
- Background
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors 2. It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins 1 and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.
- Type
- Biotech
- Groups
- Investigational
- Synonyms
- Bromelain
- Bromelain juice
- Bromelain protease
- Bromelaina
- Bromelaines
- Bromelains
- Pineapple protease
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Swelling ••• ••• ••••• ••••••• •••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bromanase 1800 Tab 225mg Tablet 225 mg Oral Nf Formulas Inc. 1984-12-31 2000-06-21 Canada 
Bromelain 250 Capsule 250 mg Oral Thorne Research Inc. 1984-12-31 2005-08-26 Canada Bromelain 500 (300gdu/capsule) Capsule 500 mg Oral Quest Vitamins A Div Of Purity Life Health Products 1993-12-31 1999-08-30 Canada Bromelain 500mg Tablets Tablet 500 mg Oral Jamieson Laboratories Ltd 1996-09-10 2000-09-08 Canada Bromelain Pineapple Enzyme 50 Mg Nu Life Tablet 50 mg Oral Nu Life Nutrition Ltd. 1963-12-31 2000-03-03 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Alka-pan Tablets Bromelains (50 mg) + Betaine hydrochloride (20 mg) + Ox bile extract (35 mg) + Pancrelipase (135 mg) + Papaya (125 mg) Tablet Oral Morter Healthsystem Not applicable Not applicable Canada BIOGROW® VITE Bromelains (12.5 mg) + Ascorbic acid (25 mg) + Beta carotene (500 IU) + Biotin (50 mcg) + Boron (50 mcg) + Calcium (2.25 mg) + Cholecalciferol (200 IU) + Choline (8.5 mg) + Chromium (10 mcg) + Copper (34 mcg) + Cyanocobalamin (2 mcg) + Folic acid (125 mcg) + Inositol (1.75 mg) + Iodine (56 mcg) + Iron (2 mg) + Magnesium (1.5 mg) + Manganese cation (750 mcg) + Molybdenum (9 mcg) + Nicotinamide (10 mg) + Pancrelipase amylase (12.5 mg) + Pantothenic acid (10 mg) + Papain (12.5 mg) + Phosphorus (2.5 mg) + Potassium (2.5 mg) + Pyridoxine (5 mg) + Riboflavin (2 mg) + Selenium (17 mcg) + Silicon (9 mcg) + Thiamine (2 mg) + Thiamine (2.5 mg) + Vanadium (4 mcg) + Vitamin A (2500 IU) + Vitamin E (15 IU) + Zinc (2 mg) Tablet Oral UNISON NUTRACEUTICALS SDN. BHD. 2020-09-08 Not applicable Malaysia 
Body Tropics Plus Tab Bromelains (50 mg) + Choline bitartrate (500 mg) + Inositol (250 mg) + Pyridoxine (25 mg) + Racemethionine (100 mg) Tablet Oral Pro Shop Inc. 1994-12-31 2008-08-02 Canada Bromelain and Papain Tab Bromelains (75 mg) + Papain (35 mg) Tablet Oral Vita Health Products Inc 1978-12-31 2002-07-31 Canada Chewable Enzymes Tablets Bromelains (15 mg) + Pancrelipase amylase (5 mg) + Papain (100 mg) Tablet Oral Gahler Enterprises Ltd. 1988-12-31 2002-07-17 Canada
Categories
- ATC Codes
- D03BA03 — Bromelains
- D03BA — Proteolytic enzymes
- D03B — ENZYMES
- D03 — PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
- D — DERMATOLOGICALS
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U182GP2CF3
- CAS number
- 9001-00-7
References
- General References
- Taussig SJ: The mechanism of the physiological action of bromelain. Med Hypotheses. 1980 Jan;6(1):99-104. [Article]
- Pavan R, Jain S, Shraddha, Kumar A: Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203. Epub 2012 Dec 10. [Article]
- Brien S, Lewith G, Walker A, Hicks SM, Middleton D: Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6. [Article]
- AIFA Product Information: NexoBrid (bromelain-enriched proteolytic enzymes) for topical use [Link]
- External Links
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Not Yet Recruiting Treatment Symptomatic Irreversible Pulpitis (SIP) 1 somestatus stop reason just information to hide 2 Completed Supportive Care Dental Decay / Plaque, Dental 1 somestatus stop reason just information to hide 2 Unknown Status Treatment Cancer 1 somestatus stop reason just information to hide 2 Unknown Status Treatment Irreversible Pulpitis (Toothache) 1 somestatus stop reason just information to hide 2 Unknown Status Treatment Mucinous Adenocarcinoma / Mucinous Tumor / Peritoneal Cancer / Pseudomyxoma Peritonei 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral Tablet, coated Oral 40 MG Tablet Oral 225 mg Capsule Oral 250 mg Capsule Oral 500 mg Tablet Oral 50 mg Powder Oral 20 mg / g Tablet Oral 500 mg Tablet Oral Tablet, sugar coated Oral Powder Cutaneous 2 G Powder Cutaneous 5 G Tablet, film coated Oral Tablet, coated Oral Tablet Oral 100 mg / tab Capsule Oral 500 mg / cap Tablet, delayed release Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at June 23, 2017 20:39 / Updated at October 10, 2024 12:49