Bromelains

Identification

Name

Bromelains

Accession Number

DB13281

Description

Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors ². It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins ¹ and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.

Type

Biotech

Groups

Investigational

Synonyms

• Bromelain
• Bromelain juice
• Bromelain protease
• Bromelaina
• Bromelaines
• Bromelains
• Pineapple protease

Pharmacology

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Indication

Not Available

Associated Conditions

• Swelling

Associated Therapies

• Eschar removal

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

Products

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Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Bromanase 1800 Tab 225mg	Tablet		Oral	Nf Formulas Inc.	1984-12-31	2000-06-21
Bromelain 250	Capsule		Oral	Thorne Research Inc.	1984-12-31	2005-08-26
Bromelain 500 (300gdu/capsule)	Capsule		Oral	Quest Vitamins A Div Of Purity Life Health Products	1993-12-31	1999-08-30
Bromelain 500mg Tablets	Tablet		Oral	Jamieson Laboratories Ltd	1996-09-10	2000-09-08
Bromelain Pineapple Enzyme 50 Mg Nu Life	Tablet		Oral	Nu Life Nutrition Ltd.	1963-12-31	2000-03-03
Bromelain Pwr	Powder		Oral	Everest Pharmaceuticals Ltd.	1979-12-31	1999-07-14
Bromelain Tab 50mg	Tablet		Oral	Country Health Laboratories Ltd.	1982-12-31	2001-07-27
Bromelain Tab 50mg	Tablet		Oral	Albi Imports Ltd.	1979-12-31	1996-09-09
Bromelain Tablet 500mg	Tablet		Oral	Royal Bodycare Canada Inc.	1993-12-31	2001-08-07
Gnc Natural Brand Tm Bromelain 100000gdu	Tablet		Oral	General Nutrition Canada Inc.	2002-10-20	2007-08-01

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Alka-pan Tablets	Bromelains (50 mg) + Betaine hydrochloride (20 mg) + Ox bile extract (35 mg) + Pancrelipase (135 mg) + Papaya (125 mg)	Tablet	Oral	Morter Healthsystem	Not applicable	Not applicable
Body Tropics Plus Tab	Bromelains (50 mg) + Choline bitartrate (500 mg) + Inositol (250 mg) + Pyridoxine (25 mg) + Racemethionine (100 mg)	Tablet	Oral	Pro Shop Inc.	1994-12-31	2008-08-02
Bromelain and Papain Tab	Bromelains (75 mg) + Papain (35 mg)	Tablet	Oral	Vita Health Products Inc	1978-12-31	2002-07-31
Chewable Enzymes Tablets	Bromelains (15 mg) + Pancrelipase amylase (5 mg) + Papain (100 mg)	Tablet	Oral	Gahler Enterprises Ltd.	1988-12-31	2002-07-17
Cilobana Cpa Tab	Bromelains (4 mg) + Ascorbic acid (150 mg) + Citrus bioflavonoids (75 mg) + Hesperidin (75 mg) + Vitamin A (10000 unit)	Tablet	Oral	Anabolic Laboratories Inc.	1968-12-31	1996-10-02
Pancreatin and Enzyme Formula - Tablet	Bromelains (50 mg) + Ox bile extract (5 mg) + Pancrelipase (350 mg) + Pancrelipase lipase (50 mg) + Pepsin (100 mg)	Tablet	Oral	Health Wise Nutrition Inc.	1997-08-15	2000-07-29
Papaya Bromelain Mycozyme	Bromelains (45 mg) + Pancrelipase amylase (30 mg) + Papain (30 mg)	Tablet	Oral	Alive Vitamins	1985-12-31	2002-07-12
PLASIL®ENZIMATICO	Bromelains (35000 U FIP) + Dehydrocholate sodium (20 mg) + Dimethicone (57.9 mg) + Metoclopramide hydrochloride (6.36 mg) + Pancrelipase (210 U FIP)	Tablet, coated	Oral		2006-11-10	Not applicable

Categories

ATC Codes

D03BA03 — Bromelains

• D03BA — Proteolytic enzymes
• D03B — ENZYMES
• D03 — PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
• D — DERMATOLOGICALS

M09AB03 — Bromelains

• M09AB — Enzymes
• M09A — OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
• M09 — OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
• M — MUSCULO-SKELETAL SYSTEM

Drug Categories

• Cysteine Endopeptidases
• Cysteine Proteases
• Dermatologicals
• Endopeptidases
• Enzymes
• Enzymes and Coenzymes
• Gastrointestinal Agents
• Hydrolases
• Musculo-Skeletal System
• Peptide Hydrolases
• Preparations for Treatment of Wounds and Ulcers

Classification

Not classified

Chemical Identifiers

UNII

U182GP2CF3

CAS number

9001-00-7

References

General References

1. Taussig SJ: The mechanism of the physiological action of bromelain. Med Hypotheses. 1980 Jan;6(1):99-104. [PubMed:7382892]
2. Pavan R, Jain S, Shraddha, Kumar A: Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203. Epub 2012 Dec 10. [PubMed:23304525]
3. Brien S, Lewith G, Walker A, Hicks SM, Middleton D: Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6. [PubMed:15841258]
4. AIFA Product Information: NexoBrid (bromelain-enriched proteolytic enzymes) for topical use [Link]

External Links

PubChem Substance

347911446

RxNav

1752

Wikipedia

Bromelain

AHFS Codes

• 56:16.00 — Digestants
• 44:00.00 — Enzymes

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
2	Completed	Supportive Care	Dental Decay / Plaque, Dental	1
2	Unknown Status	Treatment	Malignancies	1
1, 2	Not Yet Recruiting	Treatment	Adenocarcinoma, Mucinous / Malignant Peritoneal Neoplasm / Mucinous Tumor / Pseudomyxoma Peritonei	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, coated	Oral
Tablet	Oral
Capsule	Oral
Tablet	Oral
Powder	Oral
Tablet, sugar coated	Oral
Powder	Cutaneous
Tablet, film coated	Oral
Tablet, coated	Oral
Tablet, delayed release	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

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Drug created on June 23, 2017 20:39 / Updated on April 23, 2021 04:04