This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.



Bromelains is a protease indicated in the treatment of inflammation and for eschar removal.

Generic Name
DrugBank Accession Number

Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors 2. It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins 1 and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.

  • Bromelain
  • Bromelain juice
  • Bromelain protease
  • Bromelaina
  • Bromelaines
  • Bromelains
  • Pineapple protease



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Associated Conditions
Associated Therapies
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Mechanism of action
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Volume of distribution

Not Available

Protein binding

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Route of elimination

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Adverse Effects
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Pharmacogenomic Effects/ADRs
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Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
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Food Interactions
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Bromanase 1800 Tab 225mgTablet225 mgOralNf Formulas Inc.1984-12-312000-06-21Canada flag
Bromelain 250Capsule250 mgOralThorne Research Inc.1984-12-312005-08-26Canada flag
Bromelain 500 (300gdu/capsule)Capsule500 mgOralQuest Vitamins A Div Of Purity Life Health Products1993-12-311999-08-30Canada flag
Bromelain 500mg TabletsTablet500 mgOralJamieson Laboratories Ltd1996-09-102000-09-08Canada flag
Bromelain Pineapple Enzyme 50 Mg Nu LifeTablet50 mgOralNu Life Nutrition Ltd.1963-12-312000-03-03Canada flag
Bromelain PwrPowder20 mg / gOralEverest Pharmaceuticals Ltd.1979-12-311999-07-14Canada flag
Bromelain Tab 50mgTablet50 mgOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada flag
Bromelain Tab 50mgTablet50 mgOralAlbi Imports Ltd.1979-12-311996-09-09Canada flag
Bromelain Tablet 500mgTablet500 mgOralRoyal Bodycare Canada Inc.1993-12-312001-08-07Canada flag
Gnc Natural Brand Tm Bromelain 100000gduTablet50 mgOralGeneral Nutrition Canada Inc.2002-10-202007-08-01Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Alka-pan TabletsBromelains (50 mg) + Betaine hydrochloride (20 mg) + Ox bile extract (35 mg) + Pancrelipase (135 mg) + Papaya (125 mg)TabletOralMorter HealthsystemNot applicableNot applicableCanada flag
Body Tropics Plus TabBromelains (50 mg) + Choline bitartrate (500 mg) + Inositol (250 mg) + Pyridoxine (25 mg) + Racemethionine (100 mg)TabletOralPro Shop Inc.1994-12-312008-08-02Canada flag
Bromelain and Papain TabBromelains (75 mg) + Papain (35 mg)TabletOralVita Health Products Inc1978-12-312002-07-31Canada flag
Chewable Enzymes TabletsBromelains (15 mg) + Pancrelipase amylase (5 mg) + Papain (100 mg)TabletOralGahler Enterprises Ltd.1988-12-312002-07-17Canada flag
Cilobana Cpa TabBromelains (4 mg / tab) + Ascorbic acid (150 mg / tab) + Citrus bioflavonoids (75 mg / tab) + Hesperidin (75 mg / tab) + Vitamin A (10000 unit / tab)TabletOralAnabolic Laboratories Inc.1968-12-311996-10-02Canada flag
KIMOSEBromelains (50 mg) + Trypsin (1 mg)Tablet, sugar coatedOralบริษัท นิวไลฟ์ฟาร์ม่า จำกัด จำกัด1998-01-272019-10-21Thailand flag
Pancreatin and Enzyme Formula - TabletBromelains (50 mg / tab) + Ox bile extract (5 mg / tab) + Pancrelipase (350 mg / tab) + Pancrelipase lipase (50 mg / tab) + Pepsin (100 mg / tab)TabletOralHealth Wise Nutrition Inc.1997-08-152000-07-29Canada flag
Papaya Bromelain MycozymeBromelains (45 mg) + Pancrelipase amylase (30 mg) + Papain (30 mg)TabletOralAlive Vitamins1985-12-312002-07-12Canada flag
Phlogenzym - FilmtablettenBromelains (250 FIP units) + Rutoside trihydrate (100 mg) + Trypsin (1440 FIP units)Tablet, film coatedOralMucos Pharma Gmb H & Co.Kg1998-10-28Not applicableAustria flag
PLASIL®ENZIMATICOBromelains (35000 U FIP) + Dehydrocholate sodium (20 mg) + Dimethicone (57.9 mg) + Metoclopramide hydrochloride (6.36 mg) + Pancrelipase (210 U FIP)Tablet, coatedOralLABORATORIOS BUSSIE S.A2006-11-10Not applicableColombia flag


ATC Codes
D03BA03 — BromelainsM09AB03 — Bromelains
Drug Categories
Not classified
Affected organisms
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Chemical Identifiers

CAS number


General References
  1. Taussig SJ: The mechanism of the physiological action of bromelain. Med Hypotheses. 1980 Jan;6(1):99-104. [Article]
  2. Pavan R, Jain S, Shraddha, Kumar A: Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203. Epub 2012 Dec 10. [Article]
  3. Brien S, Lewith G, Walker A, Hicks SM, Middleton D: Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6. [Article]
  4. AIFA Product Information: NexoBrid (bromelain-enriched proteolytic enzymes) for topical use [Link]
PubChem Substance

Clinical Trials

Clinical Trials
2CompletedSupportive CareDental Decay / Plaque, Dental1
2Not Yet RecruitingTreatmentAdenocarcinoma, Mucinous / Malignant Peritoneal Neoplasm / Mucinous Tumor / Pseudomyxoma Peritonei1
2Not Yet RecruitingTreatmentIrreversible Pulpitis (Toothache)1
2Unknown StatusTreatmentCancer1
1, 2Not Yet RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19) / COVID-19 Acute Respiratory Distress Syndrome / COVID-19 Pneumonia / Ventilator Associated Bacterial Pneumonia (VABP)1


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Dosage Forms
Tablet, coatedOral
Tablet, coatedOral40 MG
TabletOral225 mg
CapsuleOral250 mg
CapsuleOral500 mg
TabletOral50 mg
PowderOral20 mg / g
TabletOral500 mg
Tablet, sugar coatedOral
PowderCutaneous2 G
PowderCutaneous5 G
Tablet, film coatedOral
Tablet, coatedOral
TabletOral100 mg / tab
CapsuleOral500 mg / cap
Tablet, delayed releaseOral
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Experimental Properties
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Drug created at June 23, 2017 20:39 / Updated at December 07, 2022 06:22