Bromelains

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Bromelains
Accession Number
DB13281
Description

Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors 2. It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins 1 and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.

Type
Biotech
Groups
Investigational
Synonyms
  • Bromelain
  • Bromelain juice
  • Bromelain protease
  • Bromelaina
  • Bromelaines
  • Pineapple protease

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Bromanase 1800 Tab 225mgTabletOralNf Formulas Inc.1984-12-312000-06-21Canada flag
Bromelain 250CapsuleOralThorne Research Inc.1984-12-312005-08-26Canada flag
Bromelain 500 (300gdu/capsule)CapsuleOralQuest Vitamins A Div Of Purity Life Health Products1993-12-311999-08-30Canada flag
Bromelain 500mg TabletsTabletOralJamieson Laboratories Ltd1996-09-102000-09-08Canada flag
Bromelain Pineapple Enzyme 50 Mg Nu LifeTabletOralNu Life Nutrition Ltd.1963-12-312000-03-03Canada flag
Bromelain PwrPowderOralEverest Pharmaceuticals Ltd.1979-12-311999-07-14Canada flag
Bromelain Tab 50mgTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada flag
Bromelain Tab 50mgTabletOralAlbi Imports Ltd.1979-12-311996-09-09Canada flag
Bromelain Tablet 500mgTabletOralRoyal Bodycare Canada Inc.1993-12-312001-08-07Canada flag
Gnc Natural Brand Tm Bromelain 100000gduTabletOralGeneral Nutrition Canada Inc.2002-10-202007-08-01Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Alka-pan TabletsBromelains (50 mg) + Betaine hydrochloride (20 mg) + Ox bile extract (35 mg) + Pancrelipase (135 mg) + Papaya (125 mg)TabletOralMorter HealthsystemNot applicableNot applicableCanada flag
Body Tropics Plus TabBromelains (50 mg) + Choline bitartrate (500 mg) + Inositol (250 mg) + Pyridoxine (25 mg) + Racemethionine (100 mg)TabletOralPro Shop Inc.1994-12-312008-08-02Canada flag
Bromelain and Papain TabBromelains (75 mg) + Papain (35 mg)TabletOralVita Health Products Inc1978-12-312002-07-31Canada flag
Chewable Enzymes TabletsBromelains (15 mg) + Pancrelipase amylase (5 mg) + Papain (100 mg)TabletOralGahler Enterprises Ltd.1988-12-312002-07-17Canada flag
Cilobana Cpa TabBromelains (4 mg) + Ascorbic acid (150 mg) + Citrus bioflavonoids (75 mg) + Hesperidin (75 mg) + Vitamin A (10000 unit)TabletOralAnabolic Laboratories Inc.1968-12-311996-10-02Canada flag
Pancreatin and Enzyme Formula - TabletBromelains (50 mg) + Ox bile extract (5 mg) + Pancrelipase (350 mg) + Pancrelipase lipase (50 mg) + Pepsin (100 mg)TabletOralHealth Wise Nutrition Inc.1997-08-152000-07-29Canada flag
Papaya Bromelain MycozymeBromelains (45 mg) + Pancrelipase amylase (30 mg) + Papain (30 mg)TabletOralAlive Vitamins1985-12-312002-07-12Canada flag

Categories

ATC Codes
D03BA03 — BromelainsM09AB03 — Bromelains
Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
U182GP2CF3
CAS number
9001-00-7

References

General References
  1. Taussig SJ: The mechanism of the physiological action of bromelain. Med Hypotheses. 1980 Jan;6(1):99-104. [PubMed:7382892]
  2. Pavan R, Jain S, Shraddha, Kumar A: Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203. Epub 2012 Dec 10. [PubMed:23304525]
  3. Brien S, Lewith G, Walker A, Hicks SM, Middleton D: Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6. [PubMed:15841258]
PubChem Substance
347911446
RxNav
1752
Wikipedia
Bromelains
AHFS Codes
  • 56:16.00 — Digestants
  • 44:00.00 — Enzymes

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedSupportive CareDental Decay / Plaque, Dental1
2Unknown StatusTreatmentMalignancies1
1, 2Not Yet RecruitingTreatmentAdenocarcinoma, Mucinous / Malignant Peritoneal Neoplasm / Mucinous Tumor / Pseudomyxoma Peritonei1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
TabletOral
PowderOral
TabletOral
PowderCutaneous2 G
PowderCutaneous5 G
Tablet, coatedOral35000 U FIP
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on June 23, 2017 14:39 / Updated on October 19, 2020 07:47

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