Bromelains
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Bromelains is a protease indicated in the treatment of inflammation and for eschar removal.
- Generic Name
- Bromelains
- DrugBank Accession Number
- DB13281
- Background
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors 2. It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins 1 and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.
- Type
- Biotech
- Groups
- Investigational
- Synonyms
- Bromelain
- Bromelain juice
- Bromelain protease
- Bromelaina
- Bromelaines
- Bromelains
- Pineapple protease
Pharmacology
- Indication
Not Available
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:Accelerate your drug discovery research with our fully connected ADMET dataset- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bromanase 1800 Tab 225mg Tablet 225 mg Oral Nf Formulas Inc. 1984-12-31 2000-06-21 Canada 
Bromelain 250 Capsule 250 mg Oral Thorne Research Inc. 1984-12-31 2005-08-26 Canada Bromelain 500 (300gdu/capsule) Capsule 500 mg Oral Quest Vitamins A Div Of Purity Life Health Products 1993-12-31 1999-08-30 Canada Bromelain 500mg Tablets Tablet 500 mg Oral Jamieson Laboratories Ltd 1996-09-10 2000-09-08 Canada Bromelain Pineapple Enzyme 50 Mg Nu Life Tablet 50 mg Oral Nu Life Nutrition Ltd. 1963-12-31 2000-03-03 Canada Bromelain Pwr Powder 20 mg / g Oral Everest Pharmaceuticals Ltd. 1979-12-31 1999-07-14 Canada Bromelain Tab 50mg Tablet 50 mg Oral Country Health Laboratories Ltd. 1982-12-31 2001-07-27 Canada Bromelain Tab 50mg Tablet 50 mg Oral Albi Imports Ltd. 1979-12-31 1996-09-09 Canada Bromelain Tablet 500mg Tablet 500 mg Oral Royal Bodycare Canada Inc. 1993-12-31 2001-08-07 Canada Gnc Natural Brand Tm Bromelain 100000gdu Tablet 50 mg Oral General Nutrition Canada Inc. 2002-10-20 2007-08-01 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Alka-pan Tablets Bromelains (50 mg) + Betaine hydrochloride (20 mg) + Ox bile extract (35 mg) + Pancrelipase (135 mg) + Papaya (125 mg) Tablet Oral Morter Healthsystem Not applicable Not applicable Canada Body Tropics Plus Tab Bromelains (50 mg) + Choline bitartrate (500 mg) + Inositol (250 mg) + Pyridoxine (25 mg) + Racemethionine (100 mg) Tablet Oral Pro Shop Inc. 1994-12-31 2008-08-02 Canada Bromelain and Papain Tab Bromelains (75 mg) + Papain (35 mg) Tablet Oral Vita Health Products Inc 1978-12-31 2002-07-31 Canada Chewable Enzymes Tablets Bromelains (15 mg) + Pancrelipase amylase (5 mg) + Papain (100 mg) Tablet Oral Gahler Enterprises Ltd. 1988-12-31 2002-07-17 Canada Cilobana Cpa Tab Bromelains (4 mg / tab) + Ascorbic acid (150 mg / tab) + Citrus bioflavonoids (75 mg / tab) + Hesperidin (75 mg / tab) + Vitamin A (10000 unit / tab) Tablet Oral Anabolic Laboratories Inc. 1968-12-31 1996-10-02 Canada KIMOSE Bromelains (50 mg) + Trypsin (1 mg) Tablet, sugar coated Oral บริษัท นิวไลฟ์ฟาร์ม่า จำกัด จำกัด 1998-01-27 2019-10-21 Thailand 
Pancreatin and Enzyme Formula - Tablet Bromelains (50 mg / tab) + Ox bile extract (5 mg / tab) + Pancrelipase (350 mg / tab) + Pancrelipase lipase (50 mg / tab) + Pepsin (100 mg / tab) Tablet Oral Health Wise Nutrition Inc. 1997-08-15 2000-07-29 Canada Papaya Bromelain Mycozyme Bromelains (45 mg) + Pancrelipase amylase (30 mg) + Papain (30 mg) Tablet Oral Alive Vitamins 1985-12-31 2002-07-12 Canada PLASIL�ENZIMATICO Bromelains (35000 U FIP) + Dehydrocholate sodium (20 mg) + Dimethicone (57.9 mg) + Metoclopramide hydrochloride (6.36 mg) + Pancrelipase (210 U FIP) Tablet, coated Oral LABORATORIOS BUSSIE S.A 2006-11-10 Not applicable Colombia 
Categories
- ATC Codes
- D03BA03 — Bromelains
- D03BA — Proteolytic enzymes
- D03B — ENZYMES
- D03 — PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
- D — DERMATOLOGICALS
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U182GP2CF3
- CAS number
- 9001-00-7
References
- General References
- Taussig SJ: The mechanism of the physiological action of bromelain. Med Hypotheses. 1980 Jan;6(1):99-104. [Article]
- Pavan R, Jain S, Shraddha, Kumar A: Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi: 10.1155/2012/976203. Epub 2012 Dec 10. [Article]
- Brien S, Lewith G, Walker A, Hicks SM, Middleton D: Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6. [Article]
- AIFA Product Information: NexoBrid (bromelain-enriched proteolytic enzymes) for topical use [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Supportive Care Dental Decay / Plaque, Dental 1 2 Unknown Status Treatment Malignancies 1 1, 2 Not Yet Recruiting Treatment Adenocarcinoma, Mucinous / Malignant Peritoneal Neoplasm / Mucinous Tumor / Pseudomyxoma Peritonei 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral Tablet Oral Tablet Oral 225 mg Capsule Oral 250 mg Capsule Oral 500 mg Tablet Oral 50 mg Powder Oral 20 mg / g Tablet Oral 500 mg Tablet, sugar coated Oral Powder Cutaneous Tablet, film coated Oral Tablet, coated Oral Tablet Oral 100 mg / tab Capsule Oral 500 mg / cap Tablet, delayed release Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created on June 23, 2017 20:39 / Updated on July 29, 2021 06:27