Bromelains

DB13281ApprovedInvestigationalProtein Based TherapiesGastrointestinal Agents

Bromelains is a protease indicated in the treatment of inflammation and for eschar removal. Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors.

Mechanism
Curator reviewed
First approval
Canada, 2000
Also known as
Bromelain · Bromelain juice · Bromelain protease · Bromelaines · Pineapple protease

Resolves to

Compound
UNIIU182GP2CF3CAS9001-00-7
Clinical / RWD
RxNorm1752ATCD03BA03ATCM09AB03
Targets
P01042KNG1Q02817MUC2Q8WXI7MUC16P15941MUC1P0DTC2SP98088MUC5ACQ99102MUC4Q9HC84MUC5B

What you can answer from here — as of October 01, 2026

8Protein targetsEach mapped to UniProt, with action and pharmacological action
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19Clinical trialsPhase, status and sponsor resolved per trial
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2Structured indicationsCondition, population, route and combination as fields, not prose
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12ContraindicationsEach with its own population and attribute set
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37Marketed productsAcross 6 countries and 32 labellers
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2ATC codesIncluding every combination product, plus 11 drug categories
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12+ReferencesStructured and connected to the statements they support
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