Neurogenic locus notch homolog protein 2

BE0013939ProteinHumansNOTCH2

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It is acted on by 2 drugs in DrugBank.

Gene name
NOTCH2
UniProtKB entry
Q04721Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,471 residues · 265,402 Da
Also known as
hN2 · Notch 2

Resolves to

Protein
UniProtQ04721UniProt nameNOTC2_HUMAN
Gene
HGNCHGNC:7882NCBI Gene4853GeneCardsNOTCH2
Pharmacology
IUPHAR/GtoPdb2859KEGGhsa:4853
Structure
PDB2OO4PDB5MWB
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Neurogenic locus notch homolog protein 2, and which indications are they being tested in?

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