Collagen alpha-1(VII) chain

BE0014000ProteinHumansCOL7A1

Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. It is acted on by 3 drugs in DrugBank.

Gene name
COL7A1
UniProtKB entry
Q02388Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Residues / weight
2,944 residues · 295,218 Da
Also known as
LC collagen · Long-chain collagen

Resolves to

Protein
UniProtQ02388UniProt nameCO7A1_HUMAN
Gene
HGNCHGNC:2214NCBI Gene1294GeneCardsCOL7A1
Pharmacology
KEGGhsa:1294
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Collagen alpha-1(VII) chain, how selective are they, and which programs against it are still in active trials?

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