Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

BE0014062ProteinHumansGFPT1

Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:32019926, PubMed:35229715). It is acted on by 1 drug in DrugBank.

Gene name
GFPT1
UniProtKB entry
Q06210Swiss-Prot
Residues / weight
699 residues · 78,806 Da
Also known as
2.6.1.16 · D-fructose-6-phosphate amidotransferase 1 · GFAT · GFAT 1 · GFAT1

Resolves to

Protein
UniProtQ06210UniProt nameGFPT1_HUMAN
Gene
HGNCHGNC:4241NCBI Gene2673GeneCardsGFPT1
Pharmacology
KEGGhsa:2673
Structure
PDB2V4MPDB2ZJ3PDB2ZJ4
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, and which indications are they being tested in?

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