Nuclear cap-binding protein subunit 1

BE0014101ProteinHumansNCBP1

Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs... It is acted on by 1 drug in DrugBank.

Gene name
NCBP1
UniProtKB entry
Q09161Swiss-Prot
Cellular location
Nucleus
Residues / weight
790 residues · 91,839 Da
Also known as
80 kDa nuclear cap-binding protein · CBP80 · NCBP · NCBP 80 kDa subunit

Resolves to

Protein
UniProtQ09161UniProt nameNCBP1_HUMAN
Gene
HGNCHGNC:7658NCBI Gene4686GeneCardsNCBP1
Pharmacology
KEGGhsa:4686
Structure
PDB1H2TPDB1H2UPDB1H2V
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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36GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Nuclear cap-binding protein subunit 1, and which indications are they being tested in?

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