ABX-464

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
ABX-464
Accession Number
DB14828
Description

ABX-464 is under investigation in clinical trial NCT03905109 (Safety Evaluation of ABX464 in Patients With Moderate to Severe Active Crohn's Disease).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 338.71
Monoisotopic: 338.0433751
Chemical Formula
C16H10ClF3N2O
Synonyms
Not Available
External IDs
  • ABX464

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Quinolines and derivatives
Sub Class
Aminoquinolines and derivatives
Direct Parent
Aminoquinolines and derivatives
Alternative Parents
Chloroquinolines / Aniline and substituted anilines / Phenoxy compounds / Phenol ethers / Aminopyridines and derivatives / Aryl chlorides / Imidolactams / Heteroaromatic compounds / Trihalomethanes / Azacyclic compounds
show 6 more
Substituents
Alkyl fluoride / Alkyl halide / Amine / Aminopyridine / Aminoquinoline / Aniline or substituted anilines / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide / Azacycle
show 20 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
26RU378B9V
CAS number
1258453-75-6
InChI Key
OZOGDCZJYVSUBR-UHFFFAOYSA-N
InChI
InChI=1S/C16H10ClF3N2O/c17-13-3-1-2-10-4-9-14(22-15(10)13)21-11-5-7-12(8-6-11)23-16(18,19)20/h1-9H,(H,21,22)
IUPAC Name
8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine
SMILES
FC(F)(F)OC1=CC=C(NC2=CC=C3C=CC=C(Cl)C3=N2)C=C1

References

General References
Not Available
ChemSpider
34537418

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentUlcerative Colitis1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
2CompletedTreatmentUlcerative Colitis1
2Not Yet RecruitingTreatmentCrohn's Disease (CD)1
2RecruitingTreatmentRheumatoid Arthritis2
2RecruitingTreatmentUlcerative Colitis2
2, 3RecruitingTreatmentNovel Coronavirus Infectious Disease (COVID-19)1
1CompletedTreatmentHealthy Volunteers2
1, 2CompletedTreatmentHealth Volunteers / Human Immunodeficiency Virus (HIV) Infections1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00159 mg/mLALOGPS
logP5.72ALOGPS
logP6.2ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)17.69ChemAxon
pKa (Strongest Basic)3.78ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area34.15 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity76.65 m3·mol-1ChemAxon
Polarizability29.81 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 08:29 / Updated on June 12, 2020 10:53

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