Tight junction protein 1

BE0014177ProteinHumansTJP1

TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). It is acted on by 1 drug in DrugBank.

Gene name
TJP1
UniProtKB entry
Q07157Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,748 residues · 195,457 Da
Also known as
Tight junction protein ZO-1 · ZO1 · Zona occludens protein 1 · Zonula occludens protein 1

Resolves to

Protein
UniProtQ07157UniProt nameZO1_HUMAN
Gene
HGNCHGNC:11827NCBI Gene7082GeneCardsTJP1
Pharmacology
KEGGhsa:7082
Structure
PDB2H2BPDB2H2CPDB2H3M
Drugs

What you can answer from here — as of February 11, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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39GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tight junction protein 1, how selective are they, and which programs against it are still in active trials?

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