Forkhead box protein M1

BE0014280ProteinHumansFOXM1

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). It is acted on by 1 drug in DrugBank.

Gene name
FOXM1
UniProtKB entry
Q08050Swiss-Prot
Cellular location
Nucleus
Residues / weight
763 residues · 84,282 Da
Also known as
FKHL16 · Forkhead-related protein FKHL16 · Hepatocyte nuclear factor 3 forkhead homolog 11 · HFH-11 · HFH11

Resolves to

Protein
UniProtQ08050UniProt nameFOXM1_HUMAN
Gene
HGNCHGNC:3818NCBI Gene2305GeneCardsFOXM1
Pharmacology
KEGGhsa:2305
Structure
PDB3G73PDB7FJ2PDB9XS1
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Forkhead box protein M1, how selective are they, and which programs against it are still in active trials?

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