ATP-dependent RNA helicase A

BE0014303ProteinHumansDHX9

Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation... It is acted on by 1 drug in DrugBank.

Gene name
DHX9
UniProtKB entry
Q08211Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,270 residues · 140,957 Da
Also known as
3.6.4.13 · DDX9 · DEAH box protein 9 · DExH-box helicase 9 · Leukophysin

Resolves to

Protein
UniProtQ08211UniProt nameDHX9_HUMAN
Gene
HGNCHGNC:2750NCBI Gene1660GeneCardsDHX9
Pharmacology
KEGGhsa:1660
Structure
PDB3LLMPDB3VYXPDB3VYY
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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82GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on ATP-dependent RNA helicase A, and which indications are they being tested in?

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