Ubiquitin-like protein NEDD8

BE0014813ProteinHumansNEDD8

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:14690597, PubMed:15242646, PubMed:9694792, PubMed:38605244,... It is acted on by 1 drug in DrugBank.

Gene name
NEDD8
UniProtKB entry
Q15843Swiss-Prot
Cellular location
Nucleus
Residues / weight
81 residues · 9,072 Da
Also known as
NEDD-8 · Neddylin · Neural precursor cell expressed developmentally down-regulated protein 8

Resolves to

Protein
UniProtQ15843UniProt nameNEDD8_HUMAN
Gene
HGNCHGNC:7732NCBI Gene4738GeneCardsNEDD8
Pharmacology
KEGGhsa:4738
Structure
PDB1NDDPDB1R4MPDB1R4N
Drugs

What you can answer from here — as of December 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin-like protein NEDD8, and which indications are they being tested in?

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