Pevonedistat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pevonedistat
Accession Number
DB11759
Description

Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 443.519
Monoisotopic: 443.162725003
Chemical Formula
C21H25N5O4S
Synonyms
Not Available
External IDs
  • MLN4924

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Product Ingredients
IngredientUNIICASInChI Key
Pevonedistat Hydrochloride28I8PCX76B1160295-21-5HJKDNNXKYODZJI-BVMPOVDASA-N

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Indanes
Sub Class
Not Available
Direct Parent
Indanes
Alternative Parents
Pyrrolo[2,3-d]pyrimidines / Secondary alkylarylamines / Aminopyrimidines and derivatives / Substituted pyrroles / Imidolactams / Cyclopentanols / Organic sulfuric acids and derivatives / Heteroaromatic compounds / Cyclic alcohols and derivatives / Azacyclic compounds
show 3 more
Substituents
Alcohol / Amine / Aminopyrimidine / Aromatic heteropolycyclic compound / Azacycle / Cyclic alcohol / Cyclopentanol / Heteroaromatic compound / Hydrocarbon derivative / Imidolactam
show 17 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
S3AZD8D215
CAS number
905579-51-3
InChI Key
MPUQHZXIXSTTDU-QXGSTGNESA-N
InChI
InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
IUPAC Name
[(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl]methyl sulfamate
SMILES
[H][[email protected]]1(O)C[[email protected]@]([H])(C[[email protected]@]1([H])COS(N)(=O)=O)N1C=CC2=C(N[[email protected]@]3([H])CCC4=CC=CC=C34)N=CN=C12

References

General References
Not Available
PubChem Compound
16720766
PubChem Substance
347828113
ChemSpider
17625129
ChEBI
95028
ChEMBL
CHEMBL1231160
ZINC
ZINC000058660702
PDBe Ligand
B39
Wikipedia
Pevonedistat
PDB Entries
3gzn / 5l6i

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentAcute Myeloid Leukemia (AML) / Leukemia, Myelomonocytic, Chronic / Myelodysplastic Syndrome / Novel Coronavirus Infectious Disease (COVID-19)1
3RecruitingTreatmentAcute Myeloid Leukemia (AML)1
2Active Not RecruitingTreatmentAcute Myeloid Leukemia (AML) / Leukemia, Myelomonocytic, Chronic / Myelodysplastic Syndromes (MDS)1
2Not Yet RecruitingTreatmentAcute Myeloid Leukemia (AML)1
2RecruitingTreatmentAcute, recurrent Myeloid Leukemia / Refractory Acute Myelogenous Leukemia (AML)1
2RecruitingTreatmentMetastatic Cholangiocarcinoma / Metastatic Hepatocellular Carcinoma / Stage III Hepatocellular Carcinoma AJCC v8 / Stage III Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IIIA Hepatocellular Carcinoma AJCC v8 / Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IIIB Hepatocellular Carcinoma AJCC v8 / Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IV Hepatocellular Carcinoma AJCC v8 / Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IVA Hepatocellular Carcinoma AJCC v8 / Stage IVB Hepatocellular Carcinoma AJCC v8 / Unresectable Cholangiocarcinoma / Unresectable Hepatocellular Carcinoma / Unresectable Intrahepatic Cholangiocarcinoma1
2RecruitingTreatmentMetastatic Lung Non-Small Cell Squamous Carcinoma / Metastatic Lung Non-Squamous Non-Small Cell Carcinoma / Stage IIIB Lung Cancer AJCC v8 / Stage IV Lung Cancer AJCC v8 / Stage IVA Lung Cancer AJCC v8 / Stage IVB Lung Cancer AJCC v8 / Unresectable Lung Non-Small Cell Carcinoma / Unresectable Lung Non-Squamous Non-Small Cell Carcinoma1
2RecruitingTreatmentMyelodysplastic Syndromes (MDS) / Myeloproliferative Neoplasms1
2RecruitingTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
2TerminatedTreatmentAcute Myeloid Leukemia (AML)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.136 mg/mLALOGPS
logP2.18ALOGPS
logP1.42ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)11.4ChemAxon
pKa (Strongest Basic)7.15ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area132.36 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity117.23 m3·mol-1ChemAxon
Polarizability46.22 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on October 20, 2016 14:45 / Updated on June 12, 2020 10:53

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates