Bromodomain testis-specific protein

BE0015062ProteinHumansBRDT

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). It is acted on by 5 drugs in DrugBank.

Gene name
BRDT
UniProtKB entry
Q58F21Swiss-Prot
Cellular location
Nucleus
Residues / weight
947 residues · 107,954 Da
Also known as
Cancer/testis antigen 9 · CT9 · RING3-like protein

Resolves to

Protein
UniProtQ58F21UniProt nameBRDT_HUMAN
Gene
HGNCHGNC:1105NCBI Gene676GeneCardsBRDT
Pharmacology
IUPHAR/GtoPdb2729KEGGhsa:676
Structure
PDB2RFJPDB4FLPPDB4KCX
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bromodomain testis-specific protein, and which indications are they being tested in?

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