JQ1

DB17021ExperimentalSmall molecule

First-in-class potent and selective inhibitor of the BRD4 signaling pathway.

Chemical structure of JQ1
Formula / weight
C23H25ClN4O2S · 456.99 g/mol (avg)
Also known as
(s)-(+)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate · 6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6s)- · Tert-butyl 2-((6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate
Code names
(+)-JQ1 · (S)-JQ1

Resolves to

Compound
UNII1MRH0IMX0WCAS1268524-70-4ChEMBLCHEMBL1957266ChEBI137113
Structure
InChIKeyDNVXATUJJDPFDM-KRWDZBQOSA-NSMILESCC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)OC(C)(C)C)N=C2C1=CC=C(Cl)C=C1
Targets
O60885BRD4Q58F21BRDT

What you can answer from here — as of March 06, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
3+ReferencesStructured and connected to the statements they support
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