Vesicular acetylcholine transporter

BE0015071ProteinHumansSLC18A3

Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. It is acted on by 1 drug in DrugBank.

Gene name
SLC18A3
UniProtKB entry
Q16572Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Residues / weight
532 residues · 56,903 Da
Also known as
Solute carrier family 18 member 3 · VACHT

Resolves to

Protein
UniProtQ16572UniProt nameVACHT_HUMAN
Gene
HGNCHGNC:10936NCBI Gene6572GeneCardsSLC18A3
Pharmacology
IUPHAR/GtoPdb1013KEGGhsa:6572
Structure
PDB8XTWPDB8XTXPDB8XTY
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Vesicular acetylcholine transporter, how selective are they, and which programs against it are still in active trials?

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