Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2

BE0015894ProteinHumansDEGS2

Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. It is acted on by 1 drug in DrugBank.

Gene name
DEGS2
UniProtKB entry
Q6QHC5Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
323 residues · 37,197 Da
Also known as
1.14.18.5 · 1.14.19.17 · C14orf66 · Degenerative spermatocyte homolog 2 · Sphingolipid 4-desaturase

Resolves to

Protein
UniProtQ6QHC5UniProt nameDEGS2_HUMAN
Gene
HGNCHGNC:20113NCBI Gene123099GeneCardsDEGS2
Pharmacology
KEGGhsa:123099
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2, and which indications are they being tested in?

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