Lysophosphatidylcholine acyltransferase 2
Details
- Name
- Lysophosphatidylcholine acyltransferase 2
- Kind
- protein
- Synonyms
- 1-acylglycerol-3-phosphate O-acyltransferase 11
- 1-acylglycerophosphocholine O-acyltransferase
- 1-AGP acyltransferase 11
- 1-AGPAT 11
- 1-alkenylglycerophosphocholine O-acyltransferase
- 1-alkylglycerophosphocholine O-acetyltransferase
- 2.3.1.23
- Acetyl-CoA:lyso-PAF acetyltransferase
- Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
- Acyltransferase-like 1
- AGPAT11
- AYTL1
- LPAAT-alpha
- LPC acyltransferase 2
- LPCAT-2
- Lyso-PAF acetyltransferase
- LysoPAFAT
- LysoPC acyltransferase 2
- Lysophosphatidic acid acyltransferase alpha
- Gene Name
- LPCAT2
- UniProtKB Entry
- Q7L5N7Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008839|Lysophosphatidylcholine acyltransferase 2 MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVL LGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFF SMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLR AVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPG VPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPV LFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGV RKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGL AVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDS ISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSD KKDD
- Number of residues
- 544
- Molecular Weight
- 60207.295
- Theoretical pI
- Not Available
- GO Classification
- Functions1-acylglycerol-3-phosphate O-acyltransferase activity / 1-acylglycerophosphocholine O-acyltransferase activity / 1-alkylglycerophosphocholine O-acetyltransferase activity / 2-acylglycerol-3-phosphate O-acyltransferase activity / calcium ion binding / lysophosphatidic acid acyltransferase activity / plasmalogen synthase activityProcessesmembrane organization / phosphatidylcholine acyl-chain remodeling / platelet activating factor biosynthetic processComponentsendoplasmic reticulum / endoplasmic reticulum membrane / Golgi membrane / Golgi stack / lipid droplet / plasma membrane
- General Function
- Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
- Specific Function
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 58-78
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
- Not Available
- Chromosome Location
- 16
- Locus
- 16q12.2
- External Identifiers
Resource Link UniProtKB ID Q7L5N7 UniProtKB Entry Name PCAT2_HUMAN GeneCard ID LPCAT2 HGNC ID HGNC:26032 KEGG ID hsa:54947 NCBI Gene ID 54947 - General References
- Not Available