Lysophosphatidylcholine acyltransferase 2

Details

Name
Lysophosphatidylcholine acyltransferase 2
Kind
protein
Synonyms
  • 1-acylglycerol-3-phosphate O-acyltransferase 11
  • 1-acylglycerophosphocholine O-acyltransferase
  • 1-AGP acyltransferase 11
  • 1-AGPAT 11
  • 1-alkenylglycerophosphocholine O-acyltransferase
  • 1-alkylglycerophosphocholine O-acetyltransferase
  • 2.3.1.23
  • Acetyl-CoA:lyso-PAF acetyltransferase
  • Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
  • Acyltransferase-like 1
  • AGPAT11
  • AYTL1
  • LPAAT-alpha
  • LPC acyltransferase 2
  • LPCAT-2
  • Lyso-PAF acetyltransferase
  • LysoPAFAT
  • LysoPC acyltransferase 2
  • Lysophosphatidic acid acyltransferase alpha
Gene Name
LPCAT2
UniProtKB Entry
Q7L5N7Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0008839|Lysophosphatidylcholine acyltransferase 2
MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVL
LGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFF
SMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLR
AVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPG
VPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPV
LFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGV
RKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGL
AVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDS
ISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSD
KKDD
Number of residues
544
Molecular Weight
60207.295
Theoretical pI
Not Available
GO Classification
Functions
1-acylglycerol-3-phosphate O-acyltransferase activity / 1-acylglycerophosphocholine O-acyltransferase activity / 1-alkylglycerophosphocholine O-acetyltransferase activity / 2-acylglycerol-3-phosphate O-acyltransferase activity / calcium ion binding / lysophosphatidic acid acyltransferase activity / plasmalogen synthase activity
Processes
membrane organization / phosphatidylcholine acyl-chain remodeling / platelet activating factor biosynthetic process
Components
endoplasmic reticulum / endoplasmic reticulum membrane / Golgi membrane / Golgi stack / lipid droplet / plasma membrane
General Function
Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
Specific Function
1-acylglycerol-3-phosphate O-acyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
58-78
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
Not Available
Chromosome Location
16
Locus
16q12.2
External Identifiers
ResourceLink
UniProtKB IDQ7L5N7
UniProtKB Entry NamePCAT2_HUMAN
GeneCard IDLPCAT2
HGNC IDHGNC:26032
KEGG IDhsa:54947
NCBI Gene ID54947
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Quercetinexperimental, investigationalyestargetinhibitorDetails
LuteolinexperimentalyestargetinhibitorDetails