Volume-regulated anion channel subunit LRRC8A

BE0016599ProteinHumansLRRC8A

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731,... It is acted on by 1 drug in DrugBank.

Gene name
LRRC8A
UniProtKB entry
Q8IWT6Swiss-Prot
Cellular location
Cell membrane
Residues / weight
810 residues · 94,198 Da
Also known as
HsLRRC8A · KIAA1437 · Leucine-rich repeat-containing protein 8A · LRRC8 · SWELL1

Resolves to

Protein
UniProtQ8IWT6UniProt nameLRC8A_HUMAN
Gene
HGNCHGNC:19027NCBI Gene56262GeneCardsLRRC8A
Pharmacology
KEGGhsa:56262
Structure
PDB5ZSUPDB6DJBPDB7XZH
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Volume-regulated anion channel subunit LRRC8A, and which indications are they being tested in?

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