NEDD8-activating enzyme E1 catalytic subunit

BE0017091ProteinHumansUBA3

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. It is acted on by 1 drug in DrugBank.

Gene name
UBA3
UniProtKB entry
Q8TBC4Swiss-Prot
Residues / weight
463 residues · 51,852 Da
Also known as
6.2.1.64 · NEDD8-activating enzyme E1C · UBE1C · Ubiquitin-activating enzyme 3 · Ubiquitin-activating enzyme E1C

Resolves to

Protein
UniProtQ8TBC4UniProt nameUBA3_HUMAN
Gene
HGNCHGNC:12470NCBI Gene9039GeneCardsUBA3
Pharmacology
KEGGhsa:9039
Structure
PDB1R4MPDB1R4NPDB1TT5
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on NEDD8-activating enzyme E1 catalytic subunit, and which indications are they being tested in?

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