Lysophosphatidylcholine acyltransferase 1
Details
- Name
- Lysophosphatidylcholine acyltransferase 1
- Kind
- protein
- Synonyms
- 1-acylglycerol-3-phosphate O-acyltransferase
- 1-acylglycerophosphocholine O-acyltransferase
- 1-alkenylglycerophosphocholine O-acyltransferase
- 1-alkylglycerophosphocholine O-acetyltransferase
- 2.3.1.23
- Acetyl-CoA:lyso-PAF acetyltransferase
- Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
- Acyltransferase-like 2
- AYTL2
- LPC acyltransferase 1
- LPCAT-1
- Lyso-PAF acetyltransferase
- LysoPAFAT
- LysoPC acyltransferase 1
- PFAAP3
- Phosphonoformate immuno-associated protein 3
- Gene Name
- LPCAT1
- UniProtKB Entry
- Q8NF37Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008840|Lysophosphatidylcholine acyltransferase 1 MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLV AAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGR QALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQ DSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPN KLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERAR MKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDT IQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFA EMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD
- Number of residues
- 534
- Molecular Weight
- 59150.675
- Theoretical pI
- Not Available
- GO Classification
- Functions1-acylglycerol-3-phosphate O-acyltransferase activity / 1-acylglycerophosphocholine O-acyltransferase activity / 1-alkylglycerophosphocholine O-acetyltransferase activity / 1-alkylglycerophosphocholine O-acyltransferase activity / 2-acylglycerol-3-phosphate O-acyltransferase activity / calcium ion binding / lysophosphatidic acid acyltransferase activity / plasmalogen synthase activityProcessesnegative regulation of phosphatidylcholine biosynthetic process / phosphatidic acid biosynthetic process / phosphatidylcholine acyl-chain remodeling / phosphatidylcholine biosynthetic process / phosphatidylglycerol acyl-chain remodeling / phospholipid biosynthetic process / positive regulation of protein catabolic process / protein catabolic process / retina development in camera-type eye / surfactant homeostasisComponentsazurophil granule membrane / endoplasmic reticulum / endoplasmic reticulum membrane / Golgi apparatus / Golgi membrane / lipid droplet / membrane / plasma membrane
- General Function
- Exhibits acyltransferase activity (PubMed:18156367, PubMed:21498505). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:18156367, PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
- Specific Function
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 58-78
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
- Not Available
- Chromosome Location
- 5
- Locus
- 5p15.33
- External Identifiers
Resource Link UniProtKB ID Q8NF37 UniProtKB Entry Name PCAT1_HUMAN GeneCard ID LPCAT1 HGNC ID HGNC:25718 KEGG ID hsa:79888 NCBI Gene ID 79888 - General References
- Not Available