Lysophosphatidylcholine acyltransferase 1

Details

Name
Lysophosphatidylcholine acyltransferase 1
Kind
protein
Synonyms
  • 1-acylglycerol-3-phosphate O-acyltransferase
  • 1-acylglycerophosphocholine O-acyltransferase
  • 1-alkenylglycerophosphocholine O-acyltransferase
  • 1-alkylglycerophosphocholine O-acetyltransferase
  • 2.3.1.23
  • Acetyl-CoA:lyso-PAF acetyltransferase
  • Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
  • Acyltransferase-like 2
  • AYTL2
  • LPC acyltransferase 1
  • LPCAT-1
  • Lyso-PAF acetyltransferase
  • LysoPAFAT
  • LysoPC acyltransferase 1
  • PFAAP3
  • Phosphonoformate immuno-associated protein 3
Gene Name
LPCAT1
UniProtKB Entry
Q8NF37Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0008840|Lysophosphatidylcholine acyltransferase 1
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLV
AAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGR
QALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQ
DSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPN
KLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE
ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERAR
MKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDT
IQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFA
EMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD
Number of residues
534
Molecular Weight
59150.675
Theoretical pI
Not Available
GO Classification
Functions
1-acylglycerol-3-phosphate O-acyltransferase activity / 1-acylglycerophosphocholine O-acyltransferase activity / 1-alkylglycerophosphocholine O-acetyltransferase activity / 1-alkylglycerophosphocholine O-acyltransferase activity / 2-acylglycerol-3-phosphate O-acyltransferase activity / calcium ion binding / lysophosphatidic acid acyltransferase activity / plasmalogen synthase activity
Processes
negative regulation of phosphatidylcholine biosynthetic process / phosphatidic acid biosynthetic process / phosphatidylcholine acyl-chain remodeling / phosphatidylcholine biosynthetic process / phosphatidylglycerol acyl-chain remodeling / phospholipid biosynthetic process / positive regulation of protein catabolic process / protein catabolic process / retina development in camera-type eye / surfactant homeostasis
Components
azurophil granule membrane / endoplasmic reticulum / endoplasmic reticulum membrane / Golgi apparatus / Golgi membrane / lipid droplet / membrane / plasma membrane
General Function
Exhibits acyltransferase activity (PubMed:18156367, PubMed:21498505). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:18156367, PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
Specific Function
1-acylglycerol-3-phosphate O-acyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
58-78
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
Not Available
Chromosome Location
5
Locus
5p15.33
External Identifiers
ResourceLink
UniProtKB IDQ8NF37
UniProtKB Entry NamePCAT1_HUMAN
GeneCard IDLPCAT1
HGNC IDHGNC:25718
KEGG IDhsa:79888
NCBI Gene ID79888
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Quercetinexperimental, investigationalyestargetinhibitorDetails
LuteolinexperimentalyestargetinhibitorDetails