Helicase POLQ-like

BE0017474ProteinHumansHELQ

Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:11751861, PubMed:19995904, PubMed:21398521, PubMed:24005041, PubMed:24005565, PubMed:34316696, PubMed:34937945). It is acted on by 1 drug in DrugBank.

Gene name
HELQ
UniProtKB entry
Q8TDG4Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,101 residues · 124,130 Da
Also known as
5.6.2.4 · HEL308 · Mus308-like helicase · POLQ-like helicase

Resolves to

Protein
UniProtQ8TDG4UniProt nameHELQ_HUMAN
Gene
HGNCHGNC:18536NCBI Gene113510GeneCardsHELQ
Pharmacology
KEGGhsa:113510
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Helicase POLQ-like, how selective are they, and which programs against it are still in active trials?

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