Monopotassium phosphate

Identification

Summary

Monopotassium phosphate is an ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.

Brand Names
Dextrose and Electrolyte No. 75, Ionosol-MB, Isolyte S, Isolyte S pH 7.4, Isoplate, K-phos, K-phos Neutral, K-phos No 2, Tis-U-sol
Generic Name
Monopotassium phosphate
DrugBank Accession Number
DB09413
Background

Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia by keeping pH low.

Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Structure
Thumb
Weight
Average: 136.0855
Monoisotopic: 135.932776925
Chemical Formula
H2KO4P
Synonyms
  • Monobasic potassium phosphate
  • Monopotassium dihydrogen monophosphate
  • Monopotassium dihydrogen orthophosphate
  • Monopotassium dihydrogen phosphate
  • Monopotassium monophosphate
  • Monopotassium orthophosphate
  • Phosphoric acid, monopotassium salt
  • Potassium acid phosphate
  • Potassium biphosphate
  • Potassium dihydrogen orthophosphate
  • Potassium dihydrogen phosphate
  • Potassium phosphate
  • Potassium phosphate monobasic
  • Potassium phosphate monobasic (anhydrous)
  • Potassium phosphate, monobasic
  • Potassium phosphate,monobasic
External IDs
  • E-340(I)
  • INS NO.340(I)
  • INS-340(I)

Pharmacology

Indication

Used in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Potassium is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Potassium is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism. Phosphate is a major intracellular anion that participates in providing energy for metabolism of substrates and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

Mechanism of action

hosphorus has a number of important functions in the biochemistry of the body. The bulk of the body's phosphorus is located in the bones, where it plays a key role in osteoblastic and osteoclastic activities. Enzymatically catalyzed phosphate-transfer reactions are numerous and vital in the metabolism of carbohydrate, lipid and protein, and a proper concentration of the anion is of primary importance in assuring an orderly biochemical sequence. ln addition, phosphorus plays an important role in modifying steady-state tissue concentrations of calcium. Phosphate ions are important buffers of the intracellular fluid, and also play a primary role in the renal excretion of the hydrogen ion. Oral administration of inorganic phosphates increases serum phosphate levels. Phosphates lower urinary calcium levels in idiopathic hypercalciuria.

Absorption

Potassium salts are well absorbed from the GI tract. Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption.

Volume of distribution

Potassium first enters the extracellular fluid and is then actively transported into the cells where its concentration is up to 40 times that outside the cell. Dextrose, insulin, and oxygen facilitate movement of potassium into cells.

Protein binding

In healthy adults, plasma potassium concentrations generally range from 3.5-5 mEq/L. Plasma concentrations up to 7.7 mEq/L may be normal in neonates.

Metabolism
Not Available
Route of elimination

Renal (90%) and fecal (10%) Phosphates Potassium is excreted mainly by the kidneys. Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed.

Half-life

In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.

Clearance

Phosphates are rapidly cleared by dialysis. Dialysis can also be used to treat other electrolyte abnormalities such as hypernatremia, hypocalcemia, and hypomagnesemia.

Adverse Effects
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Toxicity

Rabbit : LD50 >4640mg/kg (skin) Rat : LdLo : 4640mg/kg (Oral)

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololMonopotassium phosphate may increase the hyperkalemic activities of Acebutolol.
AceclofenacMonopotassium phosphate may increase the hyperkalemic activities of Aceclofenac.
AcemetacinMonopotassium phosphate may increase the hyperkalemic activities of Acemetacin.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Monopotassium phosphate.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Monopotassium phosphate.
AclidiniumThe therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Aclidinium.
AlclofenacMonopotassium phosphate may increase the hyperkalemic activities of Alclofenac.
AlfentanilThe therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Alfentanil.
AliskirenMonopotassium phosphate may increase the hyperkalemic activities of Aliskiren.
AlloinThe risk or severity of adverse effects can be increased when Monopotassium phosphate is combined with Alloin.
Interactions
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Food Interactions
  • Take separate from antacids. Magnesium, calcium, or aluminum antacids may reduce the absorption of phosphate in K-phos.
  • Take with a full glass of water. Dissolve K-Phos tablets in water then ingest.
  • Take with food. Take K-Phos tablets at bedtime and with meals.

Products

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Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Phosphate ionionicNK08V8K8HR14265-44-2NBIIXXVUZAFLBC-UHFFFAOYSA-K
Product Images
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
K Phos OriginalTablet, soluble500 mg/1OralBeach Products, Inc.1977-03-29Not applicableUS flag00486 1111 01 nlmimage10 4549a2ed
K Phos OriginalTablet, soluble500 mg/1OralCarilion Materials Management1977-03-29Not applicableUS flag68151 219320180907 15195 nwccib
Phosphate De Potassium Monobasic Inj 176mg/mlLiquid176 mg / mLIntravenousSandoz Canada Incorporated1987-12-31Not applicableCanada flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
DBL POTASSIUM DIHYDROGEN PHOSPHATE CONCENTRATED INJECTIONInjection1.361 gIntravenousHOSPIRA SINGAPORE PTE. LTD.1991-05-21Not applicable
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ArtisialMonopotassium phosphate (32.6 mg / 100 mL) + Calcium chloride (16.625 mg / 100 mL) + Dipotassium phosphate (80.3 mg / 100 mL) + Magnesium chloride (5.875 mg / 100 mL) + Potassium chloride (62.45 mg / 100 mL) + Sodium chloride (86.55 mg / 100 mL)LiquidBuccalJouveinal Inc.1986-12-311996-09-09Canada flag
BIOFLEKS IZOLEKS-S PH 7.4 SOL (PVC TORBA) 1000 ML SETLIMonopotassium phosphate (0.00082 g/100ml) + Dipotassium phosphate (0.012 g/100ml) + Sodium gluconate (0.5 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
Dextrose 5% and Electrolyte No75 InjMonopotassium phosphate (100 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Sodium lactate (220 mg / 100 mL) + Potassium chloride (205 mg / 100 mL) + Sodium chloride (120 mg / 100 mL)LiquidIntravenousBaxter Laboratories1990-12-312011-05-10Canada flag
Dextrose and Electrolyte No. 48Monopotassium phosphate (20 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (260 mg/100mL) + Magnesium chloride hexahydrate (31 mg/100mL) + Potassium chloride (141 mg/100mL) + Sodium chloride (12 mg/100mL)InjectionIntravenousBaxter Healthcare Corporation1979-02-02Not applicableUS flag
Dextrose and Electrolyte No. 75Monopotassium phosphate (100 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (220 mg/100mL) + Potassium chloride (205 mg/100mL) + Sodium chloride (120 mg/100mL)Injection, solutionIntravenousBaxter Laboratories2006-08-31Not applicableUS flag
ENJEKSIYONLUK POTASYUM FOSFAT 20 ML, 20 AMPULMonopotassium phosphate (0.544 g/20ml) + Dipotassium phosphate (1.394 g/20ml)InjectionIntravenousB.BRAUN MEDİKAL DIŞ TİC. A.Ş.2020-08-14Not applicableTurkey flag
Formula O-care Vitamin and Mineral SupplementMonopotassium phosphate (265.3 mg / tab) + Biotin (33.3 mcg / tab) + Calcium (333.3 mg / tab) + Cholecalciferol (133.3 unit / tab) + Copper (0.34 mg / tab) + Folic acid (0.033 mg / tab) + Magnesium (167 mg / tab) + Manganese (0.67 mg / tab) + Pyridoxine hydrochloride (1.33 mg / tab) + Riboflavin (1.1 mg / tab) + Zinc (1.67 mg / tab)TabletOralFor Mor International Inc.2000-03-252002-06-25Canada flag
Ionosol MB and DextroseMonopotassium phosphate (15 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (260 mg/100mL) + Magnesium chloride hexahydrate (30 mg/100mL) + Potassium chloride (141 mg/100mL) + Sodium phosphate, monobasic, monohydrate (25 mg/100mL)Injection, solutionIntravenousIcu Medical Inc.2019-07-01Not applicableUS flag
Ionosol MB and DextroseMonopotassium phosphate (15 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (260 mg/100mL) + Magnesium chloride hexahydrate (30 mg/100mL) + Potassium chloride (141 mg/100mL) + Sodium phosphate, monobasic, monohydrate (25 mg/100mL)Injection, solutionIntravenousHospira, Inc.2005-04-302020-04-01US flag
Isolyte S pH 7.4Monopotassium phosphate (0.00082 g/100mL) + Sodium gluconate (0.5 g/100mL) + Magnesium chloride hexahydrate (0.03 g/100mL) + Potassium chloride (0.037 g/100mL) + Sodium acetate trihydrate (0.37 g/100mL) + Sodium chloride (0.53 g/100mL) + Sodium phosphate, dibasic, unspecified form (0.012 g/100mL)Injection, solutionIntravenousB. Braun Medical Inc.1989-09-29Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BIOFLEKS IZOLEKS-S PH 7.4 SOL (PVC TORBA) 500 ML SETLIMonopotassium phosphate (0.00082 g/100ml) + Dipotassium phosphate (0.012 g/100ml) + Sodium gluconate (0.5 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-S PH7.4 500 ML SOLUSYON (PVC TORBA) SETSIZMonopotassium phosphate (0.00082 g/100ml) + Dipotassium phosphate (0.012 g/100ml) + Sodium gluconate (0.5 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralAvera McKennan Hospital2015-03-112017-05-24US flag69189 010420180907 15195 1028m42
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralAmerican Health Packaging2014-05-132020-06-30US flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralCardinal Health2012-06-282018-03-31US flag55154 767620180907 15195 nnrmgf
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralKAISER FOUNDATION HOSPITALS2014-07-072018-01-31US flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralRising Pharmaceuticals, Inc.2012-06-28Not applicableUS flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralCarilion Materials Management2012-06-28Not applicableUS flag64980 0104 01 nlmimage10 cc046643
ISOLYTE SISE 1000 ML(SETLI)Monopotassium phosphate (0.00082 %) + Sodium gluconate (0.5 %) + Magnesium chloride (0.03 %) + Potassium chloride (0.037 %) + Sodium acetate trihydrate (0.37 %) + Sodium chloride (0.53 %) + Sodium phosphate, dibasic, heptahydrate (0.012 %)SolutionIntravenousECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
ISOLYTE SISE 1000 ML(SETSIZ)Monopotassium phosphate (0.00082 %) + Sodium gluconate (0.5 %) + Magnesium chloride (0.03 %) + Potassium chloride (0.037 %) + Sodium acetate trihydrate (0.37 %) + Sodium chloride (0.53 %) + Sodium phosphate, dibasic, heptahydrate (0.012 %)SolutionIntravenousECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal phosphates
Direct Parent
Alkali metal phosphates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkali metal phosphate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
potassium salt, inorganic phosphate (CHEBI:63036)
Affected organisms
Not Available

Chemical Identifiers

UNII
4J9FJ0HL51
CAS number
7778-77-0
InChI Key
GNSKLFRGEWLPPA-UHFFFAOYSA-M
InChI
InChI=1S/K.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1
IUPAC Name
potassium dihydrogen phosphate
SMILES
[K+].OP(O)([O-])=O

References

General References
  1. Pubchem [Link]
  2. ChemIDplus [Link]
  3. DAILYMED [Link]
  4. Toxnet [Link]
PubChem Compound
516951
PubChem Substance
347827846
ChemSpider
22914
BindingDB
50004328
RxNav
34322
ChEBI
63036
ChEMBL
CHEMBL1200925
Wikipedia
Monopotassium_phosphate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingSupportive CarePostoperative Complications / Regeneration Liver1
3CompletedTreatmentHypercalciuria / Kidney Stones1
2Not Yet RecruitingTreatmentNasopharyngeal Neoplasms1
2Unknown StatusTreatmentHypophosphatemia / Osteopenia Of Prematurity1
0CompletedBasic ScienceHypoglycemic reaction1
Not AvailableUnknown StatusNot AvailableMalignant Neoplasm of Colon1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidBuccal
Injection, solutionParenteral
InjectionIntravenous1.361 g
Injection, solutionIntravenous
LiquidIntravenous
Injection, solutionIntravenous
TabletOral
SolutionIntravenous
Tablet, coatedOral
Tablet, solubleOral500 mg/1
Tablet, coatedOral186 mg
LiquidTopical
SolutionParenteral
Injection, solution
LiquidIntravenous176 mg / mL
Injection, solutionParenteral
SolutionParenteral
Injection, solution, concentrateIntravenous
TabletParenteral
InjectionIntravenous
Injection, solution, concentrateIntravenous
PowderOral
Solution
IrrigantIrrigation
SolutionIrrigation
LiquidIrrigation
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US10632150No2020-04-282039-04-19US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area80.59 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.53 m3·mol-1ChemAxon
Polarizability5.53 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created on November 30, 2015 19:10 / Updated on October 20, 2021 19:48