Carnitine O-palmitoyltransferase 1, muscle isoform

BE0017721ProteinHumansCPT1B

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. It is acted on by 4 drugs in DrugBank.

Gene name
CPT1B
UniProtKB entry
Q92523Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
772 residues · 87,800 Da
Also known as
2.3.1.21 · Carnitine O-palmitoyltransferase I, muscle isoform · Carnitine palmitoyltransferase 1B · Carnitine palmitoyltransferase I-like protein · CPT I

Resolves to

Protein
UniProtQ92523UniProt nameCPT1B_HUMAN
Gene
HGNCHGNC:2329NCBI Gene1375GeneCardsCPT1B
Pharmacology
KEGGhsa:1375
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carnitine O-palmitoyltransferase 1, muscle isoform, how selective are they, and which programs against it are still in active trials?

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