Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
- Mechanism
- Curator reviewed
Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. It acts by shifting myocardial substrate utilisation from long chain fatty acids to carbohydrates through inhibition of CPT-1 and, to a lesser extent, CPT-2, resulting in increased glucose and lactate utilization. This results in increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency.
- Primary indication
- For the management of severe angina pectoris.Curator reviewed
- Formula / weight
- C19H35N · 277.4879 g/mol (avg)
- Also known as
- Perhexilene
Resolves to
CYXKNKQEMFBLER-UHFFFAOYSA-NSMILESC(C(C1CCCCC1)C1CCCCC1)C1CCCCN1What you can answer from here — as of September 23, 2026
Which drugs share a target with Perhexiline, and which of those have an active Phase 3 trial?
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