Ubiquitin C-terminal hydrolase 7

BE0018040ProteinHumansUSP7

Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). It is acted on by 1 drug in DrugBank.

Gene name
USP7
UniProtKB entry
Q93009Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,102 residues · 128,301 Da
Also known as
3.4.19.12 · Deubiquitinating enzyme 7 · HAUSP · Herpesvirus-associated ubiquitin-specific protease · Ubiquitin thioesterase 7

Resolves to

Protein
UniProtQ93009UniProt nameUBP7_HUMAN
Gene
HGNCHGNC:12630NCBI Gene7874GeneCardsUSP7
Pharmacology
KEGGhsa:7874
Structure
PDB1NB8PDB1NBFPDB1YY6
Drugs

What you can answer from here — as of June 19, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin C-terminal hydrolase 7, and which indications are they being tested in?

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