Calcium release-activated calcium channel protein 1

BE0018211ProteinHumansORAI1

Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (Probable) (PubMed:16645049, PubMed:16733527, PubMed:16807233, PubMed:16921383, PubMed:19249086, PubMed:19706554, PubMed:23307288, PubMed:26956484, PubMed:28219928). It is acted on by 2 drugs in DrugBank.

Gene name
ORAI1
UniProtKB entry
Q96D31Swiss-Prot
Cellular location
Cell membrane
Residues / weight
301 residues · 32,668 Da
Also known as
CRACM1 · Protein orai-1 · TMEM142A · Transmembrane protein 142A

Resolves to

Protein
UniProtQ96D31UniProt nameORAI1_HUMAN
Gene
HGNCHGNC:25896NCBI Gene84876GeneCardsORAI1
Pharmacology
IUPHAR/GtoPdb2964KEGGhsa:84876
Structure
PDB2MAKPDB4EHQ
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Calcium release-activated calcium channel protein 1, and which indications are they being tested in?

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