E3 ubiquitin-protein ligase pellino homolog 1

BE0018269ProteinHumansPELI1

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). It is acted on by 1 drug in DrugBank.

Gene name
PELI1
UniProtKB entry
Q96FA3Swiss-Prot
Cellular location
Chromosome
Residues / weight
418 residues · 46,286 Da
Also known as
2.3.2.27 · Pellino-1 · Pellino-related intracellular-signaling molecule · PRISM · RING-type E3 ubiquitin transferase pellino homolog 1

Resolves to

Protein
UniProtQ96FA3UniProt namePELI1_HUMAN
Gene
HGNCHGNC:8827NCBI Gene57162GeneCardsPELI1
Pharmacology
KEGGhsa:57162
Structure
PDB9IF9
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on E3 ubiquitin-protein ligase pellino homolog 1, and which indications are they being tested in?

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