Mas-related G protein-coupled receptor member X2

BE0018408ProteinHumansMRGPRX2

Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109, PubMed:34789874, PubMed:34789875). It is acted on by 6 drugs in DrugBank.

Gene name
MRGPRX2
UniProtKB entry
Q96LB1Swiss-Prot
Cellular location
Cell membrane
Residues / weight
330 residues · 37,099 Da
Also known as
MRGX2

Resolves to

Protein
UniProtQ96LB1UniProt nameMRGX2_HUMAN
Gene
HGNCHGNC:17983NCBI Gene117194GeneCardsMRGPRX2
Pharmacology
IUPHAR/GtoPdb157KEGGhsa:117194
Structure
PDB7S8LPDB7S8MPDB7S8N
Drugs

What you can answer from here — as of June 19, 2026

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mas-related G protein-coupled receptor member X2, how selective are they, and which programs against it are still in active trials?

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