Ferroptosis suppressor protein 1

BE0018843ProteinHumansAIFM2

A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed:31634899, PubMed:31634900, PubMed:35922516, PubMed:36788244, PubMed:37957306, PubMed:39881208, PubMed:37739993, PubMed:39160155, PubMed:38414669, PubMed:40233740). It is acted on by 3 drugs in DrugBank.

Gene name
AIFM2
UniProtKB entry
Q9BRQ8Swiss-Prot
Cellular location
Lipid droplet
Residues / weight
373 residues · 40,526 Da
Also known as
1.6.5.- · AMID · Apoptosis-inducing factor homologous mitochondrion-associated inducer of death · FSP1 · p53-responsive gene 3 protein

Resolves to

Protein
UniProtQ9BRQ8UniProt nameFSP1_HUMAN
Gene
HGNCHGNC:21411NCBI Gene84883GeneCardsAIFM2
Pharmacology
KEGGhsa:84883
Structure
PDB8JSCPDB8WIKPDB8YO8
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ferroptosis suppressor protein 1, how selective are they, and which programs against it are still in active trials?

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