Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.
- Mechanism
- Curator reviewed · 8 references
Vitamin K is a cofactor of gamma-carboxylase. Gamma carboxylase attaches carboxylic acid functional groups to glutamate, allowing precursors of factors II, VII, IX, and X to bind calcium ions. Binding of calcium ions converts these clotting factors to their active form, which are then secreted from hepatocytes into the blood, restoring normal clotting function.
Vitamin K may also carboxylate matrix proteins in chondrocytes, inhibiting calcification of joints, and may increase type II collagen. The role of vitamin K in osteroarthritis, bone density, and vascular calcification is currently under investigation.
- Primary indication
- Oral phylloquinone is indicated to treat prothrombin deficiency caused by coumarin or indanedione derivatives; and hypoprothrombinemia secondary to antibacterial therapy, salicylates, or obstructive jaundice or biliary fistulas with concomitant bile salt administration.Curator reviewed · 17 structured indications
- Formula / weight
- C31H46O2 · 450.6957 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1955
- Also known as
- 3-Phytylmenadione · alpha-Phylloquinone · Phytomenadione · Phytonadione · Phytylmenadione
- Code names
- NSC-270681
- Brand names
Resolves to
MBWXNTAXLNYFJB-NKFFZRIASA-NSMILESCC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Vitamin K1, and which of those have an active Phase 3 trial?
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