Mitogen-activated protein kinase kinase kinase 5

BE0018876ProteinHumansMAP3K5

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 3 drugs in DrugBank.

Gene name
MAP3K5
UniProtKB entry
Q99683Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,374 residues · 154,535 Da
Also known as
2.7.11.25 · Apoptosis signal-regulating kinase 1 · ASK-1 · ASK1 · MAPK/ERK kinase kinase 5

Resolves to

Protein
UniProtQ99683UniProt nameM3K5_HUMAN
Gene
HGNCHGNC:6857NCBI Gene4217GeneCardsMAP3K5
Pharmacology
IUPHAR/GtoPdb2080KEGGhsa:4217
Structure
PDB2CLQPDB3VW6PDB4BF2
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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34GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 5, how selective are they, and which programs against it are still in active trials?

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