Serine/threonine-protein kinase PINK1, mitochondrial

BE0019132ProteinHumansPINK1

Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress (PubMed:40080546). It is acted on by 1 drug in DrugBank.

Gene name
PINK1
UniProtKB entry
Q9BXM7Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
581 residues · 62,768 Da
Also known as
2.7.11.1 · BRPK · PTEN-induced putative kinase protein 1

Resolves to

Protein
UniProtQ9BXM7UniProt namePINK1_HUMAN
Gene
HGNCHGNC:14581NCBI Gene65018GeneCardsPINK1
Pharmacology
KEGGhsa:65018
Structure
PDB9EIHPDB9EIIPDB9EIJ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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90GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PINK1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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