N-acetylneuraminate lyase

BE0019134ProteinHumansNPL

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (PubMed:33895133). It is acted on by 1 drug in DrugBank.

Gene name
NPL
UniProtKB entry
Q9BXD5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
320 residues · 35,162 Da
Also known as
4.1.3.3 · C1orf13 · N-acetylneuraminate pyruvate-lyase · N-acetylneuraminic acid aldolase · NALase

Resolves to

Protein
UniProtQ9BXD5UniProt nameNPL_HUMAN
Gene
HGNCHGNC:16781NCBI Gene80896GeneCardsNPL
Pharmacology
KEGGhsa:80896
Structure
PDB6ARH
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on N-acetylneuraminate lyase, and which indications are they being tested in?

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