Disintegrin and metalloproteinase domain-containing protein 33

BE0019245ProteinHumansADAM33

Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation (PubMed:14676211, PubMed:33982767). It is acted on by 1 drug in DrugBank.

Gene name
ADAM33
UniProtKB entry
Q9BZ11Swiss-Prot
Cellular location
Cell membrane
Residues / weight
813 residues · 87,738 Da
Also known as
3.4.24.- · ADAM 33 · C20orf153

Resolves to

Protein
UniProtQ9BZ11UniProt nameADA33_HUMAN
Gene
HGNCHGNC:15478NCBI Gene80332GeneCardsADAM33
Pharmacology
IUPHAR/GtoPdb1673KEGGhsa:80332
Structure
PDB1R54PDB1R55
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Disintegrin and metalloproteinase domain-containing protein 33, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In