Alpha-(1,6)-fucosyltransferase

BE0019374ProteinHumansFUT8

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (PubMed:17172260, PubMed:29304374, PubMed:36280670, PubMed:9133635). It is acted on by 1 drug in DrugBank.

Gene name
FUT8
UniProtKB entry
Q9BYC5Swiss-Prot
Cellular location
Golgi apparatus, Golgi stack membrane
Residues / weight
575 residues · 66,515 Da
Also known as
2.4.1.68 · Alpha1-6FucT · Fucosyltransferase 8 · GDP-fucose--glycoprotein fucosyltransferase · GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase

Resolves to

Protein
UniProtQ9BYC5UniProt nameFUT8_HUMAN
Gene
HGNCHGNC:4019NCBI Gene2530GeneCardsFUT8
Pharmacology
KEGGhsa:2530
Structure
PDB2DE0PDB6TKVPDB6VLD
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
14GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
6+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Alpha-(1,6)-fucosyltransferase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In