Poly [ADP-ribose] polymerase tankyrase-2

BE0019375ProteinHumansTNKS2

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). It is acted on by 3 drugs in DrugBank.

Gene name
TNKS2
UniProtKB entry
Q9H2K2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,166 residues · 126,917 Da
Also known as
2.4.2.30 · ADP-ribosyltransferase diphtheria toxin-like 6 · ARTD6 · PARP5B · Poly [ADP-ribose] polymerase 5B

Resolves to

Protein
UniProtQ9H2K2UniProt nameTNKS2_HUMAN
Gene
HGNCHGNC:15677NCBI Gene80351GeneCardsTNKS2
Pharmacology
IUPHAR/GtoPdb3109KEGGhsa:80351
Structure
PDB2Y0IPDB3KR7PDB3KR8
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Poly [ADP-ribose] polymerase tankyrase-2, and which indications are they being tested in?

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