DNA-directed RNA polymerase I subunit RPA49

BE0019377ProteinHumansPOLR1E

Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025, PubMed:34887565, PubMed:36271492). It is acted on by 1 drug in DrugBank.

Gene name
POLR1E
UniProtKB entry
Q9GZS1Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
419 residues · 47,260 Da
Also known as
DNA-directed RNA polymerase I subunit E · PAF53 · PRAF1 · RNA polymerase I subunit A49 · RNA polymerase I-associated factor 1

Resolves to

Protein
UniProtQ9GZS1UniProt nameRPA49_HUMAN
Gene
HGNCHGNC:17631NCBI Gene64425GeneCardsPOLR1E
Pharmacology
KEGGhsa:64425
Structure
PDB7OB9PDB7OBAPDB7OBB
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase I subunit RPA49, and which indications are they being tested in?

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