Thioredoxin-interacting protein

BE0019558ProteinHumansTXNIP

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). It is acted on by 1 drug in DrugBank.

Gene name
TXNIP
UniProtKB entry
Q9H3M7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
391 residues · 43,661 Da
Also known as
Thioredoxin-binding protein 2 · VDUP1 · Vitamin D3 up-regulated protein 1

Resolves to

Protein
UniProtQ9H3M7UniProt nameTXNIP_HUMAN
Gene
HGNCHGNC:16952NCBI Gene10628GeneCardsTXNIP
Pharmacology
KEGGhsa:10628
Structure
PDB4GEIPDB4GEJPDB4GFX
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thioredoxin-interacting protein, and which indications are they being tested in?

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