NAV

Ruscogenin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Ruscogenin is an anti-inflammatory steroid used in combination with local anesthetics for the treatment of hemorrhoids and for local anesthesia.

Generic Name
Ruscogenin
DrugBank Accession Number
DB15830
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 430.629
Monoisotopic: 430.308309832
Chemical Formula
C27H42O4
Synonyms
Not Available
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination for symptomatic treatment ofHemorrhoidsCombination Product in combination with: Trimebutine (DB09089)•••••••••••••••••• •••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Ruscorectal
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
PROCTOLOG RECTAL KREM, 30 GRuscogenin (0.5 g/100g) + Trimebutine (5.8 g/100g)CreamRectalPFİZER İLAÇLARI LTD. ŞTİ.2011-08-122022-04-19Turkey flag
PROCTOLOG SUPOZITUAR, 10 ADETRuscogenin (10 mg) + Trimebutine (120 mg)SuppositoryRectalPFİZER İLAÇLARI LTD. ŞTİ.2011-08-022023-01-10Turkey flag
PROCTOLOG SUPPOSITORYRuscogenin (10 mg) + Trimebutine (120 mg)SuppositoryRectalPFIZER PRIVATE LIMITED1989-06-03Not applicableSingapore flag
RECBUTIN % 5.8 + % 0.5 REKTAL KREM, 30 GRuscogenin (5 mg) + Trimebutine (58 mg)CreamRectalABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.2013-09-11Not applicableTurkey flag
RECBUTIN 120 MG/10 MG SUPOZITUVAR, 10 ADETRuscogenin (10 mg) + Trimebutine (120 mg)SuppositoryRectalABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.2013-09-10Not applicableTurkey flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
BXI92R2VUJ
CAS number
472-11-7
InChI Key
QMQIQBOGXYYATH-IDABPMKMSA-N
InChI
InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
IUPAC Name
(1'S,2R,2'S,4'S,5R,7'S,8'R,9'S,12'S,13'R,14'R,16'R)-5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18'-ene-14',16'-diol
SMILES
[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)C[C@@H](O)[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2

References

General References
  1. AIFA: Ruscoroid (Ruscogenin / Tetracaine) cutaneous cream [Link]
KEGG Drug
D08498
KEGG Compound
C08909
ChemSpider
390469
RxNav
35890
ChEBI
8913
ChEMBL
CHEMBL1169820
ZINC
ZINC000008234225

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Unknown StatusPreventionNausea / Vomiting1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamRectal
SuppositoryRectal
SuppositoryRectal10 mg
CreamCutaneous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00821 mg/mLALOGPS
logP3.08ALOGPS
logP3.62Chemaxon
logS-4.7ALOGPS
pKa (Strongest Acidic)14.45Chemaxon
pKa (Strongest Basic)-2.8Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area58.92 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity121.74 m3·mol-1Chemaxon
Polarizability51.73 Å3Chemaxon
Number of Rings6Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-03e9-0010900000-07561358f9bc8b93e6fa
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0000900000-0f036850930c5991cf24
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-0194500000-453a405aaf7dafd2e75a
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004r-0008900000-78c3b60f0039359b89b4
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-0493100000-2ba6f8f664b8fae904dc
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-020a-0109500000-836536db94be8d5104e7
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-215.9578778
predicted
DarkChem Lite v0.1.0
[M-H]-184.72023
predicted
DeepCCS 1.0 (2019)
[M+H]+216.1838778
predicted
DarkChem Lite v0.1.0
[M+H]+186.61565
predicted
DeepCCS 1.0 (2019)
[M+Na]+214.4798778
predicted
DarkChem Lite v0.1.0
[M+Na]+192.37932
predicted
DeepCCS 1.0 (2019)

Drug created at September 14, 2020 16:39 / Updated at May 14, 2021 01:08