DNA-directed RNA polymerase I subunit RPA2

BE0019741ProteinHumansPOLR1B

Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. It is acted on by 1 drug in DrugBank.

Gene name
POLR1B
UniProtKB entry
Q9H9Y6Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
1,135 residues · 128,228 Da
Also known as
2.7.7.6 · DNA-directed RNA polymerase I 135 kDa polypeptide · RNA polymerase I subunit 2 · RPA135

Resolves to

Protein
UniProtQ9H9Y6UniProt nameRPA2_HUMAN
Gene
HGNCHGNC:20454NCBI Gene84172GeneCardsPOLR1B
Pharmacology
KEGGhsa:84172
Structure
PDB7OB9PDB7OBAPDB7OBB
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase I subunit RPA2, and which indications are they being tested in?

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