Neuroglobin

BE0019827ProteinHumansNGB

Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed:11473128, PubMed:12962627, PubMed:24699645). It is acted on by 1 drug in DrugBank.

Gene name
NGB
UniProtKB entry
Q9NPG2Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
151 residues · 16,933 Da
Also known as
Nitrite reductase

Resolves to

Protein
UniProtQ9NPG2UniProt nameNGB_HUMAN
Gene
HGNCHGNC:14077NCBI Gene58157GeneCardsNGB
Pharmacology
KEGGhsa:58157
Structure
PDB1OJ6PDB4MPMPDB7VQG
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Neuroglobin, how selective are they, and which programs against it are still in active trials?

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