NADPH oxidase 4

BE0019855ProteinHumansNOX4

NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (PubMed:14966267, PubMed:15356101, PubMed:15927447, PubMed:21343298, PubMed:25062272). It is acted on by 5 drugs in DrugBank.

Gene name
NOX4
UniProtKB entry
Q9NPH5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
578 residues · 66,931 Da
Also known as
1.6.3.1 · Kidney oxidase-1 · Kidney superoxide-producing NADPH oxidase · KOX-1 · Renal NAD(P)H-oxidase

Resolves to

Protein
UniProtQ9NPH5UniProt nameNOX4_HUMAN
Gene
HGNCHGNC:7891NCBI Gene50507GeneCardsNOX4
Pharmacology
IUPHAR/GtoPdb3004KEGGhsa:50507
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADPH oxidase 4, how selective are they, and which programs against it are still in active trials?

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