Non-lysosomal glucosylceramidase
BE0020281ProteinHumansGBA2
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17105727, PubMed:30308956, PubMed:32144204). It is acted on by 3 drugs in DrugBank.
- Gene name
- GBA2
- UniProtKB entry
- Q9HCG7Swiss-Prot
- Cellular location
- Endoplasmic reticulum membrane
- Residues / weight
- 927 residues · 104,648 Da
- Also known as
- 3.2.1.45 · Beta-glucocerebrosidase 2 · Beta-glucosidase 2 · Bile acid beta-glucosidase GBA2 · Bile acid glucosyl transferase GBA2
Resolves to
Pharmacology
Drugs
What you can answer from here — as of September 03, 2024
Which approved drugs act on Non-lysosomal glucosylceramidase, how selective are they, and which programs against it are still in active trials?
Create a free account or log in to explore the full data card.
Create Account