Sialic acid-binding Ig-like lectin 8

BE0020378ProteinHumansSIGLEC8

Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells (PubMed:10625619, PubMed:10856141). It is acted on by 1 drug in DrugBank.

Gene name
SIGLEC8
UniProtKB entry
Q9NYZ4Swiss-Prot
Cellular location
Membrane
Residues / weight
499 residues · 54,042 Da
Also known as
SAF-2 · SAF2 · Sialoadhesin family member 2 · Siglec-8

Resolves to

Protein
UniProtQ9NYZ4UniProt nameSIGL8_HUMAN
Gene
HGNCHGNC:10877NCBI Gene27181GeneCardsSIGLEC8
Pharmacology
KEGGhsa:27181
Structure
PDB2N7APDB2N7BPDB7QU6
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Sialic acid-binding Ig-like lectin 8, and which indications are they being tested in?

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