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Lirentelimab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Lirentelimab
DrugBank Accession Number
DB16728
Background

Lirentelimab is under investigation in clinical trial NCT04856891 (A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Duodenitis).

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Antolimab
  • IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS SIALIC ACID-BINDING IG-LIKE LECTIN 8 (SIALOADHESIN FAMILY MEMBER 2, SIGLEC-8, SAF-2))HUMANIZED MOUSE MONOCLONAL ANTIBODY.GAMMA.1 HEAVY CHAIN (1-450) (VH (HOMO SAPIENS IGHV3-66*01 (79%) (IGHD)-IGHJ5*01 (91%)/MUS
  • IMMUNOGLOBULIN G1, ANTI-(HUMAN SIALIC ACID-BINDINGE IG-LIKE LECTIN 8) (HUMAN-MUS MUSCULUS MONOCLONAL AK002 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL AK002 .KAPPA.-CHAIN, DIMER
  • Lirentelimab
  • MONOCLONAL ANTIBODY AK002
  • Recombinant humanized, non-fucosylated IgG1 anti-Siglec-8 monoclonal antibody
External IDs
  • AK 002
  • AK-002
  • AK002
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
SWS48LJU3T
CAS number
2283348-97-8

References

General References
Not Available
Wikipedia
Lirentelimab

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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3CompletedTreatmentEosinophilic Duodenitis / Eosinophilic Gastritis2somestatusstop reasonjust information to hide
3CompletedTreatmentEosinophilic Duodenitis / Eosinophilic Gastroenteritis1somestatusstop reasonjust information to hide
3WithdrawnTreatmentEosinophilic Duodenitis / Eosinophilic Gastritis1somestatusstop reasonjust information to hide
2CompletedTreatmentChronic Urticaria1somestatusstop reasonjust information to hide
2CompletedTreatmentEosinophilic Duodenitis / Eosinophilic Gastritis / Eosinophilic Gastroenteritis1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
Not Available

Drug created at September 02, 2021 20:47 / Updated at October 05, 2023 17:34