Interleukin-37

BE0020499ProteinHumansIL37

Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. It is acted on by 2 drugs in DrugBank.

Gene name
IL37
UniProtKB entry
Q9NZH6Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
218 residues · 24,126 Da
Also known as
FIL1 zeta · FIL1Z · IL-1 zeta · IL-1F7 · IL-1H

Resolves to

Protein
UniProtQ9NZH6UniProt nameIL37_HUMAN
Gene
HGNCHGNC:15563NCBI Gene27178GeneCardsIL37
Pharmacology
KEGGhsa:27178
Structure
PDB5HN1PDB6NCU
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-37, how selective are they, and which programs against it are still in active trials?

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