Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

BE0020615ProteinHumansHCN3

Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). It is acted on by 1 drug in DrugBank.

Gene name
HCN3
UniProtKB entry
Q9P1Z3Swiss-Prot
Cellular location
Cell membrane
Residues / weight
774 residues · 86,031 Da
Also known as
KIAA1535

Resolves to

Protein
UniProtQ9P1Z3UniProt nameHCN3_HUMAN
Gene
HGNCHGNC:19183NCBI Gene57657GeneCardsHCN3
Pharmacology
IUPHAR/GtoPdb402KEGGhsa:57657
Structure
PDB8INZPDB8IO0PDB8IO3
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, and which indications are they being tested in?

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